![]() (2019) Skeletal Muscles Do Not Undergo Apoptosis During Either Atrophy or Programmed Cell Death- Rejection of The Myonuclear Domain Hypothesis. Tsuji J, Thomson T, Chan E, Brown CK, Oppenheimer J, Bigelow C, Dong X, Theurkauf WE, Weng Z, Schwartz LM. (2020) High Resolution Analysis of Differential Gene Expression During Skeletal Muscle Atrophy and Programmed Cell Death. ![]() (2020)Acheron/LARP6 is a Novel Survival Protein that Controls Programmed Cell Death During Development. Sheel, A, Shao, R., Brown, C., Johnson, J., Hamilton, A., Oppenheimer, J., Smith, W., Visconti, P., Markstein, M., and Schwartz, L.M. (2019) Skeletal Muscles Do Not Undergo Apoptosis During Either Atrophy or Programmed Cell Death-Revisiting the Myonuclear Domain Hypothesis. We are currently expanding this analysis to examine skeletal muscle disorders in mammals. Recently, we performed a comprehensive RNA-seq transcriptomics analysis of both the mRNAs and small RNAs to identify all of the differentially expressed genes, as well as the microRNAs that regulate their stability and translatability. The ability of the ISMs to commit suicide requires de novo gene expression, and we have use a variety of molecular techniques to clone death-associated transcripts from these cells. These giant cells are used to propel the moth out of the pupal cuticle at the end of metamorphosis, and then they die during a 30 hr period in response to a specific hormonal trigger. ![]() To define the molecular mechanisms that mediate this process, we have exploited the intersegmental muscles (ISM) of moth as a model system. Defects in the regulation of cell death serves as the basis of many human diseases, including auto-immunity, neurodegeneration and most cancers. Programmed cell death is a fundamental component of development and homeostasis in virtually all organisms.
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